Novel cholangioscopy‐guided targeted biopsy for diagnosing gallbladder carcinoma

Watch a video of this article. Gallbladder (GB) lesions can be diagnosed using several imaging modalities; however, their definitive diagnosis remains challenging. Bile cytology demonstrates unsatisfactory accuracy for GB lesions.1, 2 To improve diagnostic ability, targeted biopsy under direct vision is desirable. Conversely, with the advancement cholangioscopy, has become possible, and bile duct improved.3-5 We report first case carcinoma cholangioscopy-guided biopsy. A 65-year-old man was referred to our hospital obstructive jaundice due common (CBD) stones, which appeared during cholecystitis treatment at referring hospital. Contrast-enhanced computed tomography showed 20-mm-diameter low-density area on liver bed around (Fig. 1a) cystic dilation in coronal image 1b). Magnetic resonance cholangiopancreatography numerous stones observed from CBD 1c). distinguish benign pericholecystic abscesses malignant carcinoma, transpapillary attempted after obtaining informed consent. Post-endoscopic sphincterotomy guidewire placed GB. cholangioscope caliber 3.3 mm (CHF-B290; Olympus, Tokyo, Japan) advanced into assistance 2a). maintain clear view, intraluminal cleaned saline injection without air insufflation. papillary lesion an irregular surface pattern noted fundus 2b), suspected tumor. Targeted biopsies were performed forceps (FB-44U-1; Olympus) 2c,d), resulting histological adenocarcinoma 2e Video S1). He then underwent surgical intervention, mass as invasion carcinoma. This procedure may feasible diagnosing selective cases dilated straight duct. Authors declare no conflicts interests Please note: The publisher not responsible content or functionality any supporting information supplied by authors. Any queries (other than missing content) should directed corresponding author